ANTl-CD154 ANTIBODY HAVING IMPROVED BINDING, FUNCTIONAL AND SAFETY CHARACTERISTICS AND USE IN HUMAN IMMUNOTHERAPY.

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专利权人:

IMMUNEXT; INC.

发明人:

HEARN, Arron,HOLGATE, Robert,ROTHSTEIN, Jay

申请号：

TN2018000021

公开号：

TN2018000021A1

申请日:

2016.07.13

申请国别(地区):

TN

年份:

2019

代理人:

摘要：

Improved anti-CD 154 antibodies are provided herein which have improved therapeutic potency, in vivo half-life and ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation, transplant recipients, fibrosis and allergie disorders is disclosed herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/