PROCEDE POUR L'ELABORATION D'UN AGENT ANTITUMORAL, LA 6-(7-((1-AMINO-CYCLO-PROPYL)-METHOXY)-6- METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE,ET DE SA FORME CRISTALLINE

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专利权人:

LLC;ADVENCHEN PHARMACEUTICALS

发明人:

CHEN, GUOQING PAUL

申请号：

CA2896898

公开号：

CA2896898A1

申请日:

2014.01.17

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention relates a new process to synthesize 6-(7-((l-aminocyclo-propyl)- methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl- l -naphthamide (AL3810) by deprotection of substituted benzyl 1 -((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)- methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((l-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N- methyl- 1 -naphthamide has also been prepared.

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