DEFREES, SHAWN A.,JOHNSON, KARL FRANK,WANG, ZHI-GUANG
申请号：
CA2518171
公开号：
CA2518171C
申请日:
2004.03.04
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A compound having the formula (seeabove formula) , wherein Z is amember selected from O, S, C(R2)2 and NR2； X is a member selected from H,¨OR3, ¨NR3R4, ¨SR3, and -CHR3R4； R2, R3 and R4 are members independently selectedfromH, substituted or unsubstituted alkyl, substituted or unsubstitutedheteroalkyl,substituted or unsubstituted aryl, substituted or unsubstitutedheteroaryl,substituted orunsubstituted heterocycloalkyl, -C(=M)R5, -C(=M)-Z-R5, -SO2R5, and -SO3；whereinM and Z are members independently selected from O, NR6 and S； Y is a memberselected from H, -OR7, -SR7, -NR7R8, substituted or unsubstituted alkyl,substituted orunsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted orunsubstituted heteroaryl, and substituted or unsubstituted heterocycloalkyl；whereinR5, R6, R7 and R8 are members independently selected from H, substituted orunsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted orunsubstituted aryl, substituted or unsubstituted heteroaryl, substituted orunsubstitutedheterocycloalkyl； R11 and R12 are members independently selected fromsubstituted orunsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted orunsubstituted aryl, substituted or unsubstituted heteroaryl, substituted orunsubstitutedhetero cyclo alkyl, NR14R15, OR14, -CN and ¨C(=L)R14； wherein L is a memberselected from O, S, and NR16； R13 is selected from substituted orunsubstitutedheterocycloalkyl, OR17 and NR17R18； and R14 and R15 is selected from H,substitutedor unsubstituted alkyl, substituted or nsubstituted heteroalkyl, substitutedorunsubstituted aryl, substituted or unsubstituted heteroaryl, substituted orunsubstitutedheterocycloalkyl, C(O)R17, OR17 and NR17¨ 18； wherein R16, R17 and R18 aremembersindependently selected from H, substituted or unsubstituted alkyl, substitutedorunsubstituted heteroalkyl, substituted
