PROBLEM TO BE SOLVED: To provide a model nonhuman animal that causes a sudden death by an idiopathic myocardial disease.SOLUTION: There is provided a heart-specific PHGPx (phospholipid hydroperoxide glutathione peroxidase) deficient nonhuman animal which is given vitamin E in a minimum amount for survival, which is an idiopathic myocardial disease model nonhuman animal that causes a sudden death by an idiopathic myocardial disease when an exercise load is given.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】特発性心筋症による突然死を起こすモデル非ヒト動物を提供する。【解決手段】生存可能な最低量のビタミンEを与えた心臓特異的PHGPx(リン脂質ヒドロペルオキシドグルタチオンペルオキシダーゼ)欠損非ヒト動物であり、運動負荷を与えると特発性心筋症による突然死を起こす、特発性心筋症モデル非ヒト動物。【選択図】なし
