FORMULATIONS PHARMACEUTIQUES TOPIQUES CONTENANT UNE FAIBLE CONCENTRATION DE PEROXYDE DE BENZOYLE EN SUSPENSION DANS DE L'EAU ET UN SOLVANT ORGANIQUE MISCIBLE AVEC L'EAU
An aqueous formulation for topical application to the skin comprising water, awater-miscible organic solvent, andbenzoyl peroxide, wherein the concentration of the organic solvent issufficient to provide a stable suspension of benzoyl peroxidein the aqueous formulation without the inclusion of a surfactant in theformulation, wherein the ratio of concentrations of waterand organic solvent in the formulation is sufficient to maintain the benzoylperoxide in saturated solubility in the formulation followingapplication to the skin, and wherein the concentration of benzoyl peroxide inthe formulation is less than 5.0% and at least1.0% w/w. The formulation may further contain a chemical compound in additionto benzoyl peroxide that is effective in the treatmentof acne. The aqueous formulations of the invention are useful in the treatmentof acne and acne rosacea.
