MEANWELL NICHOLAS A.,HIEBERT SHELDON,RAJAMANI RAMKUMAR,SUN LI-QIANG,MULL ERIC,GILLIS ERIC P.,BOWSHER MICHAEL S.,ZHAO QIAN,RENDUCHINTALA KISHORE V.,SARKUNAM KANDHASAMY,NAGALAKSHMI PULICHARLA,BABU P.V.K
申请号：
NZ61859412
公开号：
NZ618594A
申请日:
2012.05.01
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are macrocyclic peptide-based inhibitors of hepatitis C virus (HCV) compounds of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 1,1,1-trifluoro-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinolin-1-yloxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-1-yl)oxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate and (2R,6S,7R,9R,13aR,14aR,16aS)-6-(3-(tert-butyl)ureido)-N-((1- (fluoromethyl)cyclopropyl)sulfonyl)-2-((4-methoxyisoquinolin-1-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide.
