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Use of PTEN-long leader sequence for transmembrane delivery of molecules
专利权人:
The Trustees of Columbia University in the City of New York
发明人:
Parsons, Ramon
申请号:
AU2011218037
公开号:
AU2011218037B2
申请日:
2011.02.17
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
A composition for delivering cargo molecules across biological membranes is provided comprising (i) a peptide comprising consecutive amino acid residues having the sequence set forth in SEQ ID NO 1 for the transport of a cargo molecule across a biological membrane and (ii) the cargo molecule, wherein the cargo molecule is not a peptide comprising amino acid residues having the sequence set forth in SEQ ID NO 4. Methods of delivering cargo molecules across biological membranes are also provided. Methods of treating a tumor, cancer, a metabolic disorder, and a cardiovascular disorder are also provided.
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