A portable medical examination device used for cancer detection using tissue illumination with radiation of a certain wavelength band to provide the operator with either reflected images of the tissue or by inducing visible fluorescence of the irradiated tissue. The medical examination device has an illumination source transmitting a light beam through a first lens unit to condition the light beam a fiber optic bundle including an excitation fiber and an image fiber, wherein the excitation fiber delivers the conditioned light from the first lens unit to a tissue to be examined and wherein the image fiber directs the light emanating from the illuminated tissue to a second lens unit and an angularly adjustable visualization unit, wherein a light beam conditioned by the second lens unit is visualized by the device operator and/or captured by an image capture device.