MAHON, KERRY PETER,LOVE, KEVIN THOMAS,LEVINS, CHRISTOPHER G.,WHITEHEAD, KATHRYN ANN,LANGER, ROBERT S.,ANDERSON, DANIEL GRIFFITH
申请号：
CA2742954
公开号：
CA2742954C
申请日:
2009.11.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided are: a pH-sensitive carrier for a physiologicallyactive substance, which can respond to a weakly acidicenvironment to promote a membrane-disrupting function； a methodfor producing the carrier； a pH-sensitive medicine and apH-sensitive pharmaceutical composition, each containing thecarrier； and a corresponding culture method. A pH-sensitivecarrier which can exhibit an effect of promoting a membrane-disrupting function, comprising: at least one pH-sensitivecompound selected from the group consisting of deoxycholic acid,cholic acid, ursodeoxycholic acid, chenodeoxycholic acid,hyodeoxycholic acid, a higher bile acid, glycodeoxycholic acid,glycyrrhizic acid, glycyrrhetinic acid and salts thereof； and atleast one amphipathic substance selected from the groupconsisting of a phosphatidylcholine having 10 to 12 carbon atoms,a polyoxyethylene sorbitan mono-fatty acid ester having 12 to 18carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbonatoms, glycerol monooleate, glycerol dilaurate, glyceroldistearate, glycerol d'oleate, polyoxyethylene castor oil andu-tocopherol.
