BOGEN, STEPHANE L.,MA, YAO,WANG, YAOLIN,LAHUE, BRIAN ROBERT,NAIR, LATHA G.,SHIZUKA, MANAMI,VOSS, MATTHEW ERNST,KIROVA-SNOVER, MARGARITA,PAN, WEIDONG,TIAN, YUAN,KULKARNI, BHEEMASHANKAR A.,GIBEAU, CRAIG
申请号：
PE2012000472
公开号：
PE20121172A1
申请日:
2010.10.05
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
The invention relates to a formula of Pichia derivative (1),Among them, R1 is an unorthodox group； it either does not exist or is h, halo, oh, CN, o-tar C1-C6, etc.； J is h or halogen； y is O, s, SO2, cr8r8 '；R IS C1-C6-ALKYL, (CR8R8 ') n-C (O) OH； G IS (CR8R8 ') n-C (O) OH, C (O) OH, AMONG OTHERS； R8 AND R8 'ARE H, C1-C6 ALKYL, AMONG OTHERS； n IS AN INTEGER FROM 0 TO 10； R2 IS (a) O (b)；R4, R4',R5, R5',R6, R6',R7 and R7 'are h or C1-C6 asphalt； X is (c) or (d). These compounds are inhibitors of human secondary micro protein (hm2), which can be used to treat cancer, abnormal cell proliferation diseases, and diseases caused by insufficient p53 content.REFERIDA A UN DERIVADO DE PIPERIDINA DE FORMULA (1), DONDE R1 ES UN GRUPO HETEROCICLO； E ESTA AUSENTE O ES H, HALO, OH, CN, O-ALQUILO C1-C6, ENTRE OTROS； J ES H O HALOGENO； Y ES O, S, SO2, CR8R8'； R ES ALQUILO C1-C6, (CR8R8')n-C(O)OH； G ES (CR8R8')n-C(O)OH, C(O)OH, ENTRE OTROS； R8 Y R8' SON H, ALQUILO C1-C6, ENTRE OTROS； n ES UN ENTERO DE 0 A 10； R2 ES (a) O (b)； R4, R4', R5, R5', R6, R6', R7 Y R7' SON H O ALQUILO C1-C6； X ES (c) O (d). DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DOBLE DIMINUTO HUMANA 2 (HDM2) Y SON UTILES EN EL TRATAMIENTO DE CANCER, ENFERMEDADES PROLIFERATIVAS DE CELULAS ANORMALES, ENFERMEDADES CAUSADAS POR NIVELES DE p53 INADECUADOS, ENTRE OTRAS
