BOGEN, STEPHANE L.,MA, YAO,WANG, YAOLIN,LAHUE, BRIAN ROBERT,NAIR, LATHA G.,SHIZUKA, MANAMI,VOSS, MATTHEW ERNST,KIROVA-SNOVER, MARGARITA,PAN, WEIDONG,TIAN, YUAN,KULKARNI, BHEEMASHANKAR A.,GIBEAU, CRAIG
申请号：
PE0004722012
公开号：
PE11722012A1
申请日:
2010.10.05
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a piperidine Derivative of formula (1), wherein R1 is a group is absent or heterocycle e h, Halo, Oh, CN, or c1-c6 alkyl, among others J is H or Halogen and o, S, SO2, cr8r8 R is alkyl C1 C6 (cr8r8) n - C (o) o G Is (cr8r8 ) - C (o) C (o) Oh, Oh, among others R8 and R8 are h, alkyd ILO C1 - C6, among others n is an integer from 0 to 10 R2 is (a) or (b) R4, R4, R5, R6 R5, R6 ,,R6 and R7 are H or c1-c6 alkyl X is (c) or (d). These compounds are inhibitors of protein 2 (Double diminutive Human Hdm2) and are useful in the treatment of cancer, abnormal Cell proliferative diseases, Diseases caused by inadequate levels of p53, among othersREFERIDA A UN DERIVADO DE PIPERIDINA DE FORMULA (1), DONDE R1 ES UN GRUPO HETEROCICLO E ESTA AUSENTE O ES H, HALO, OH, CN, O-ALQUILO C1-C6, ENTRE OTROS J ES H O HALOGENO Y ES O, S, SO2, CR8R8 R ES ALQUILO C1-C6, (CR8R8)n-C(O)OH G ES (CR8R8)n-C(O)OH, C(O)OH, ENTRE OTROS R8 Y R8 SON H, ALQUILO C1-C6, ENTRE OTROS n ES UN ENTERO DE 0 A 10 R2 ES (a) O (b) R4, R4, R5, R5, R6, R6, R7 Y R7 SON H O ALQUILO C1-C6 X ES (c) O (d). DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DOBLE DIMINUTO HUMANA 2 (HDM2) Y SON UTILES EN EL TRATAMIENTO DE CANCER, ENFERMEDADES PROLIFERATIVAS DE CELULAS ANORMALES, ENFERMEDADES CAUSADAS POR NIVELES DE p53 INADECUADOS, ENTRE OTRAS
