Colin M. Tice;Wei He;Yuanjie Ye;Wei Zhao;Zhenrong Xu;Salvacion Cacatian;Linghang Zhuang;Suresh B. Singh;David A. Claremon
发明人:
Salvacion Cacatian,David A. Claremon,Wei He,Suresh B. Singh,Colin M. Tice,Zhenrong Xu,Yuanjie Ye,Wei Zhao,Linghang Zhuang
申请号：
US12745663
公开号：
US09079861B2
申请日:
2008.11.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih)1 (Ij), (Ik), (Il1-3). (Im1-3), (In1-3), (Io1-2), (Ip1-6), (Iq1-6), (Ir1-6) and (Is1-2), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
