CHANG, EDCON,NOTZ, WOLFGANG REINHARD LUDWIG,WALLACE, MICHAEL B.
申请号：
PE2015000013
公开号：
PE20150754A1
申请日:
2013.07.08
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The invention refers to a compound of Formula 1 and a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are defined in memory. The present disclosure also relates to materials and methods for the preparation of Formula 1 compounds, pharmacological ingredients containing these ingredients and their use in the treatment of immune disorders, cardiovascular diseases, cancer and other diseases, diseases and diseases related to p13kd. The preferred compounds are: (s) 5-chloro-n4 - (1 - (1-methyl-1-methyl-6 - (1-methyl-1h-pyrazol-5-il) - 1h-pirolol [3,2-b] pyridine-5-il) ethyl) pyridine-2,4-diamine；(s) - 2,4-diamino-6 - (1 - (1 - (1-methyl-1h-pirazol-5-il) - 1 h-pirrolo [3,2-b] piridin-5-il) ethyl) amino) pirimdina-5-carbon；(s) - 2-amine-4-methyl-6 - (1 - (1-methyl-6 - (1-methyl-1h-pyrazol-5-il) - 1h-pirolol [3, 2-B] pyridine-5-il) ethyl) dimethyl carbamate-5-carbonate；Among other thingsLa invencion se refiere a los compuestos de la Formula 1, y una de sus sales farmaceuticamente aceptables, donde R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 se definen en la memoria. La presente revelacion tambien se refiere a los materiales y metodos para preparar compuestos de la Formula 1, a composiciones farmaceuticas que los contienen y a su empleo para tratar trastornos inmunologicos, enfermedades cardiovasculares, cancer y otros trastornos, enfermedades y afecciones que se asocian con la P13Kdelta. Son compuestos preferidos: (S)5-Cloro-N4-(1-(1-metil-6-(1-metil-1H-pirazol-5-il) -1H-pirrolo[3,2-b]piridin-5-il)etil)pirimidina-2 ,4-diamina； (S)-2 ,4-Diamino-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo ； (S)-2-Amino-4-metil-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3 ,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo ； entre otros
