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Method for screening therapeutic agent for Alzheimer's disease and transgenic non-human animal
专利权人:
国立研究開発法人国立長寿医療研究センター
发明人:
津田 玲生,林 永美
申请号:
JP2011085642
公开号:
JP5876664B2
申请日:
2011.04.07
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a method for screening an unerring therapeutic agent for dementia at an individual level.SOLUTION: A transgenic non-human animal in which a dementia-related gene is expressed is created by introducing an expression vector carrying the dementia-related gene into the inner ear hair cells of a non-human animal being a test subject. A candidate compound is administered to a transgenic non-human animal in which the dementia-related gene is expressed. Sense of hearing of the transgenic non-human animal in which the candidate compound is administered is detected. In such a case where the degree of hearing disorder in a transgenic non-human animal in which a candidate compound is administered is more dissolved than the degree of hearing disorder in a transgenic non-human animal in which a candidate compound is not administered, the candidate compound is determined to be effective as a therapeutic agent for dementia.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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