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Glycosylation IN BIRDS
专利权人:
СИНАДЖЕВА БАЙОФАРМА КОРП. (US)
发明人:
ХАРВИ Алекс Дж. (US)
申请号:
RU2010133175/10
公开号:
RU2010133175A
申请日:
2009.01.07
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A transgenic bird containing a transgene containing a glycosyltransferase coding sequence, wherein the tissue of the transgenic bird's oviduct produces a protein comprising an N-linked oligosaccharide containing at least one saccharide, where the oligosaccharide will not contain a saccharide in the absence of a transgene. ! 2. The transgenic bird according to claim 1, in which the glycosyltransferase is N-acetylglucosaminyl transferase. ! 3. The transgenic bird according to claim 1, in which the glycosyltransferase is N-acetylglucosaminyl transferase 3.! 4. The transgenic bird according to claim 1, wherein the oviduct tissue is magnum tissue. ! 5. The transgenic bird according to claim 1, in which the tissue of the oviduct represents the cells of the tubular gland. ! 6. The transgenic bird according to claim 1, in which the cells of the tissue of the oviduct secrete protein in the presence of egg white. ! 7. The transgenic bird according to claim 1, in which the transgene contains LTR. ! 8. The transgenic bird according to claim 1, in which the transgene contains an oviduct specific promoter. ! 9. A method comprising isolating a protein produced by a transgenic bird according to claim 1. ! 10. The transgenic bird according to claim 1, in which the protein is exogenous to the bird. ! 11. A method comprising isolating an exogenous protein produced by a transgenic bird of claim 10. ! 12. The transgenic bird according to claim 1, in which the protein is a medicinal protein. ! 13. The method according to claim 11, in which the bird is a chicken. ! 14. A transgenic bird containing a transgene containing the galactosyl transferase coding sequence, where the transgenic bird's oviduct tissue produces a protein comprising an N-linked oligosaccharide containing at least one galactose, where the oligosaccharide will not contain galactos1. Трансгенная птица, содержащая трансген, содержащий кодирующую последовательность гликозилтрансферазы, где ткань яйцевода трансгенной птицы
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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