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Substituted pyrazole compounds
专利权人:
William J. Pitts;Scott Hunter Watterson;Alaric J. Dyckman
发明人:
Alaric J. Dyckman,William J. Pitts,Scott Hunter Watterson
申请号:
US13145728
公开号:
US08389509B2
申请日:
2010.01.22
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Disclosed are compounds of Formula (I)or a pharmaceutically acceptable salt thereof, wherein: n is zero or an integer selected from 1 through 4; R1 is cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, benzyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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