William J. Pitts;Scott Hunter Watterson;Alaric J. Dyckman
发明人:
Alaric J. Dyckman,William J. Pitts,Scott Hunter Watterson
申请号：
US13145728
公开号：
US08389509B2
申请日:
2010.01.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are compounds of Formula (I)or a pharmaceutically acceptable salt thereof, wherein: n is zero or an integer selected from 1 through 4； R1 is cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, benzyl, —OR4, and/or halogen； and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
