Juan Fernando Vera Valdes,Cliona M. Rooney,Ann Marie Leen,Norihiro Watanabe
申请号：
US16743987
公开号：
US20200140520A1
申请日:
2020.01.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGFβ receptor including the exodomain of a TGFβII receptor and an endodomain that is not from TGFβ receptor, thereby converting the negative signal of TGFβ for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGFβ receptor also harbor one or more chimeric antigen receptors.
