Hong LIU,Pengbo ZHANG,Lucas HORAN,Yiyang XU,Binnaz K. STALEY,Lianxing LIU,Hongruo YUN
申请号：
US16660515
公开号：
US20200115448A1
申请日:
2019.10.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.
