Jon Krueger Fairweather;Vito Ferro;Tomislav Karoli;Ligong Liu
发明人:
Vito Ferro,Jon Krueger Fairweather,Tomislav Karoli,Ligong Liu
申请号：
US12960145
公开号：
US08173606B2
申请日:
2010.12.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase； methods for the preparation of the compounds； compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
