A plant cultivation device is provided, including a cultivation frame body (10), a plurality of hydroponic bases (20), a soil cultivation base (30), a plurality of filter bases (40), a water storage base (50) and a plurality of lights (60), the cultivation frame body having a frame (11), wo sides of a top surface of the frame of the cultivation frame body each having a front rod (12) and an rear rod (13), a plurality of hold bases being disposed between and on the front rods, the plurality of hold bases (121) respectively having three layer hydroponic bases, each of which is hollow and has a plurality of cultivation holes (201), each of the hold bases corresponding to one of the lights, the soil cultivation base, the soil cultivation base having a bell syphon with a drain tube (81) disposed thereinside, the water storage base having a submersible pump (100) and an external inlet tube (70).