Various examples of methods, systems and devices are provided for ophthalmic examination. In one example, a handheld system includes an optical imaging assembly coupled to a user device that includes a camera aligned with optics of the optical imaging assembly. The user device can obtain ocular imaging data of at least a portion of an eye via the optics of the optical imaging assembly and provide ophthalmic evaluation results based at least in part upon the ocular imaging data. In another example, a method includes receiving ocular imaging data of at least a portion of an eye analyzing the ocular imaging data to determine at least one ophthalmic characteristic of the eye and determining a condition based at least in part upon the at least one ophthalmic characteristic.