ABSTRACTHepatitis C Virus Polymerase Inhibitors With A Heterobicyclic StructureAn isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is 0, S, NR[err], or CR[err], wherein R[err] is defined herein； represents either a single or a double bond； R[err] is selected from: H, halogen, R[err], OR[err], SR[err], COOR[err], SO[err]N(R[err])[err], N(R[err])[err], CON(R[err])[err], NR[err]C(O)R[err] or NR[err]C(O)NR[err] wherein R[err] and each R[err] is defined herein； B is NR[err] or CR[err], with the proviso that one of A or B is either CR[err] or CR[err], wherein R[err] is defined herein； K is N or CR[err], wherein R[err] is defined herein； L is N or CR[err], wherein R[err] has the same definition as R[err]； M is N or CR[err], wherein R[err] has the same definition as R[err]； Y[err] is 0 or S； Z is N(R[err])R[err] or OR[err], wherein R[err] is H or alkyl or NR[err]R[err] wherein R[err] and R[err] are defined herein； and R[err] is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het； or R[err] is wherein R[err] and R[err] and Q are as defined herein； Y[err] is 0 or S； R[err] is H, (C[err] alkyl), (C[err])cycloalkyl or (C[err])alkyl-(C[err])cycloalkyl, aryl, Het, (C[err])alkyl-aryl or (C[err]- [err])alkyl-Het, all of which optionally substituted with R[err]； or R[err] is covalently bonded to either of R[err] or R[err] to form a 5- or 6-membered heterocycle； a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.
