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NEUROTOXINES PRÉSENTANT UNE ACTIVITÉ BIOLOGIQUE RÉDUITE
专利权人:
Merz Pharma GmbH & Co. KGaA;MERZ PHARMA GMBH & CO KGAA
发明人:
申请号:
EP10726549.8
公开号:
EP2449101B1
申请日:
2010.07.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation signal in the light chain of the neurotoxin polypeptide as well as vectors and host cells comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
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