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encoded polynucleotide a neurotoxin polypeptide, vector, host cell, antibody, use of a polynucleotide, method for making a neurotoxin polypeptide, and method for making a medicament
专利权人:
MERZ PHARMA GMBH & CO. KGAA
发明人:
FRED HOFMANN,JÜRGEN FREVERT
申请号:
BRPI1014253
公开号:
BRPI1014253A2
申请日:
2010.07.01
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation signal in the light chain of the neurotoxin polypeptide as well as vectors and host cells comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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