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COMPOSES DE 4-ISOPROPYLPHENYL GLUCITOL COMME INHIBITEURS DE SGLT1
专利权人:
TAISHO PHARMACEUTICAL CO.; LTD.
发明人:
KAKINUMA, HIROYUKI,KOBASHI, YOHEI,CHONAN, TOMOMICHI,OI, TAKAHIRO,SHIOZAWA, FUMIYASU,IWATA, YUKI,KAWABE, KENICHI
申请号:
CA2752212
公开号:
CA2752212C
申请日:
2010.02.23
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention provides 4-isopropylphenyl glucitol compounds which haveno tendency to accumulate inthe body and which inhibit SGLT1 activity to suppress postprandialhyperglycemia (or impaired glucose tolerance) through suppressionof glucose absorption in the small intestine, whereby the compounds, forexample, can suppress the onset of diabetes andmetabolic syndrome or can treat these diseases. A 4-isopropylphenyl glucitolcompound represented by the following formula (I)or a pharmaceutically acceptable salt thereof: [Chem. 1] wherein R1 representsa hydrogen atom, etc., R2 represents a methylgroup, etc., R3 represents a C1-4 alkyl group substituted with an aminogroup(s), etc., and R4 represents a hydrogen atom, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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