A compound of Formula I: ** (See formula) ** in which: R3 is selected from the group consisting of: C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, NR10R11 C1-6 alkyl, R 10 heterocyclyl C 1-6 alkyl, R 10 aryl C 1-6 alkyl, and R 10 heteroaryl C 1-6 alkyl, wherein R 10 and R 11 are each independently selected from the group consisting of: hydrogen and C 1-6 alkyl； E is selected from the group consisting of: -NR13C (O) CR14>； = CHR15, and -NR13C (O) C≡CR14, in which R13 is selected from the group consisting of: hydrogen and methyl, and R14 and R15 are each independently selected from the group consisting of: hydrogen, methyl, fluoro and chloro； R 12 is selected from the group consisting of: hydrogen, halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 hydroxy-alkoxy-C 1-6 alkoxy-C 1-6 alkoxy, alkoxy C1-6-C1-6 alkyl, R5R6 heterocyclyl, -C (O) heterocyclyl R5R6, R5R6 heterocyclyl C1-6 alkyl, NR5R6, NR5R6 C1-6 alkyl, -C (O) NR5R6, and NR5R6-C1-6 alkoxy, which R5 and R6 are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, -C (O) C1-6 alkyl and C1-6 alkyl -sulfonyl； and R1 is phenyl, wherein said phenyl is substituted 2, 3, or 4 times with independently selected halo or C1-6 alkoxy, or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I: **(Ver fórmula)** en la que: R3 se selecciona del grupo que consiste en: alquilo de C1-6, alcoxi C1-6-alquilo de C1-6, NR10R11alquilo de C1-6, R10heterociclilalquilo de C1-6, R10arilalquilo de C1-6, y R10heteroarilalquilo de C1-6, en los que R10 y R11 se seleccionan cada uno independientemente del grupo que consiste en: hidrógeno y alquilo de C1-6； E se selecciona del grupo que consiste en: -NR13C(O)CR14>；=CHR15, y -NR13C(O)C≡CR14, en las que R13 se selecciona del grupo que consiste en: hidrógeno y metilo, y R14 y R15 se seleccionan cada uno independientemente del grupo que consiste en: hidrógeno, metilo, fluoro y cloro； R12 se selecciona del grupo que consist
