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PRÉPARATIONS DE LIPOPLEX POUR UNE ADMINISTRATION SPÉCIFIQUE DANS UN ENDOTHÉLIUM VASCULAIRE
专利权人:
Silence Therapeutics GmbH
发明人:
申请号:
EP15161527.5
公开号:
EP2992875A1
申请日:
2007.04.20
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention is related to a lipid composition contained in and/or containing a carrier comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is optionally removable from the lipid composition under in vivo conditions, whereby the lipid composition containing carrier has an osmolality of about 50 to 600 mosmole/kg, preferably about 250 - 350 mosmole/kg, and more preferably about 280 to 320 mosmole/kg, and/or whereby liposomes formed by the first lipid component and/or one or both of the helper lipid and the shielding compound in the carrier have a particle size of about 20 to 200 nm, preferably about 30 to 100 nm, and more preferably about 40 to 80 nm.
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