Matthew Franco Myntti;Brian Vaccaro;Dana A. Oliver
发明人:
Matthew Franco Myntti,Dana A. Oliver,Brian Vaccaro
申请号：
US12429120
公开号：
US09198997B2
申请日:
2009.04.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Tissue and other body structures may be protected using a hydrated composition made from free-flowing rehydratable particles or a rehydratable sponge comprising substantially collagen-free dehydrothermally crosslinked thiolated polysaccharide. Rehydration of crosslinked or uncrosslinked polysaccharide particles may be carried out without clumping by dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated particles or sponge may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
