At present, pyrethroids have inhibitory effect on a 500 enzyme with T790M mutation in the European Patent and Trademark Association, which can be used to prevent and / or treat the positive cancer with T790M mutation in the European Patent and Trademark Association； another way is to achieve the positive lung cancer with T790M mutation in the European Patent and trademark Association； Even in another form of labor, there is also non-small cell lung cancer with T790M mutation in EFR； in another form of labor, there is positive protein cancer with T790M mutation in egrf； in another form of labor, there is positive protein lung cancer with T790M mutation in egrf.Even if it's realized in different ways, cancer of thyroid hormone inhibitor of antigenic gastroenteritis, even if it's realized in different ways, lung cancer of thyroid hormone of antigenic gastroenteritis, and another different way, Lung cancer non-small cell antigenic thyroid hormone quinase, in EFR and similar. 1. Claim 1: a compound of formula (1) or its salts, wherein R1 represents the lower replaceable asphalt - or the lower replaceable asphalt - nh832222；-NH - replaceable lower asphalt, - n (replaceable lower asphalt)-L83088 cyclopentyl compound (alternative), L83088 arilo (alternative), L83088 alternative heterocyclic aromatic group, o-l83088 alternative non aromatic heterocyclic group； a ring represents alternative sand or alternative heterocyclic aromatic cycle； 1. Representative - o-o-nh -；R2 stands for H, halogen, oh, No. 8309； r8310a,-CONH₂,-Cn, - L 830808 cyclopentyl compound (replaceable), - L 830808 arilo (replaceable), - L 830808 - replaceable heterocyclic aromatic group, - L 830808 - replaceable non aromatic heterocyclic group, - L 830808； Replaced； L2 stands for - or-S (O) -- en...-N (CH) --NHCH₂-,-NHCH₂CH₂-,-8.8322 - or a combination； represents an X-ring or a combination； an X-ring represents an alternative ring methane, an alternative sand, an alternative aromatic or an alternative non a
