The present invention relates to a pharmaceutical composition for preventing or treating IL-6 (interleukin-6) -mediated disease, which comprises a flower extract of Rosa rugosa as an active ingredient, and said composition as an IL-6-mediated disease. To a method for treating an IL-6 mediated disease comprising administering to an individual suspected of The present invention also relates to a food composition, a quasi-drug composition, and a feed composition for preventing or ameliorating an IL-6 mediated disease, which contains a flower extract of Hermanus as an active ingredient. The present invention inhibits IL-6-induced signaling system and suppresses osteoclast differentiation, thereby allowing IL-6 mediated diseases such as bone metabolic diseases, inflammatory bowel diseases, or atopy. It can be usefully used in the prevention or treatment of atopic dermatitis, and in particular, unlike other parts of the extract, it is not cytotoxic and has no side effects derived from natural products that have been used in food for a long time. There are advantages to be used in the treatment of the above diseases. [Selection] Figure 1本発明は、ハマナス（Rosa rugosa）の花抽出物を有効成分として含む、ＩＬ－６（interleukin-6）媒介性疾患の予防又は治療用薬学的組成物及び前記組成物をＩＬ－６媒介性疾患の疑いのある個体に投与する段階を含む、ＩＬ－６媒介性疾患の治療方法に関する。また、本発明は、ハマナスの花抽出物を有効成分として含む、ＩＬ－６媒介性疾患の予防又は改善用食品組成物、医薬部外品組成物及び飼料組成物に関する。本発明は、ＩＬ－６により誘導されるシグナル伝達システムを阻害し、破骨細胞の分化を抑制することにより、ＩＬ－６媒介性疾患、例えば、骨代謝性疾患、炎症性腸疾患、又はアトピー性皮膚炎の予防又は治療において有用に用いることができ、特に、他の部位の抽出物とは異なり、細胞毒性がなく、長い間、食品に用いられてきた天然物に由来して副作用がなく、前記疾患の治療に用いられる利点がある。【選択図】 図１
