THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WYETH
发明人:
WALSH, FRANK S.,ZALESKA, MARGARET M.,HOWLAND, DAVID S.,HOLZBAUR-HOWLAND, ERIKA L.F.,TCHISTIAKOVA, LIOUDMILA,KARIM, RIYEZ,KELLEY, PAMELA,TAN, XIANG-YANG,KWAK, SEUNG POON,WALLACE, KAREN,WEBER, NICHOLAS
申请号：
CA2619491
公开号：
CA2619491C
申请日:
2006.08.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The disclosure provides novel molecules related to growth and differentiationfactor-8 (GDF-8), in particular mouse and humanized antibodies, and antibodyfragments, including those that inhibit GDF-8 activity and signaling in vitroand/or in vivo. The disclosure also provides methods for diagnosing, treating,ameliorating, preventing, prognosing, or monitoring degenerative orders ofmuscle, bone, and insulin metabolism, etc., in particular amyotrophic lateralsclerosis (ALS). In addition, the disclosure provides pharmaceuticalcompositions for the treatment of such disorders by using the antibodies,polypeptides, polynucleotides, and vectors of the invention.
