The Trustees of the University of Pennsylvania;Wyeth
发明人:
Weber, Nicholas,Wallace, Karen,Kwak, Seung Poon,Tan, Xiang-Yang,Pangalos, Menelas N.,Holzbaur-Howland, Erika L.F.,Karim, Riyez,Kelley, Pamela,Walsh, Frank S.,Howland, David S.,Zaleska, Margaret M.,Tch
申请号：
AU2006283725
公开号：
AU2006283725B2
申请日:
2006.08.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The disclosure provides novel molecules related to growth and differentiationfactor-8 (GDF-8), in particular mouse and humanized antibodies, and antibodyfragments, including those that inhibit GDF-8 activity and signaling and/or . The disclosure also provides methods for diagnosing,treating, ameliorating, preventing, prognosing, or monitoring degenerativeorders of muscle, bone, and insulin metabolism, etc., in particular amyotrophiclateral sclerosis (ALS). In addition, the disclosure provides pharmaceuticalcompositions for the treatment of such disorders by using the antibodies, polypeptides,polynucleotides, and vectors of the invention.
