Balkrishen Bhat,Thazha P. Prakash,Charles Allerson,Garth A. Kinberger,Eric G. Marcusson,Eric E. Swayze
申请号：
US13566864
公开号：
US20130035369A1
申请日:
2012.08.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides double stranded compositions wherein the first strand is modified to have a particular motif and the second strand is modified a selected motif. More particularly, the present compositions comprise an antisense strand that is modified to have a positional/full motif and the sense strand is modified to have an alternating motif, a hemimer motif, a blockmer motif, a gapped motif, a positional motif, a positional/full motif or a fully modified motif. Each strand further comprises one or more phosphorothioate internucleoside linkage. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes.
