The present invention provides methods and compositions comprising a chimeric norovirus capsid protein comprising a norovirus VP1 major capsid protein backbone comprising a norovirus epitope and/or motif selected from the group consisting of: a) Epitope A b) Epitope B c) Epitope C d) Epitope D e) Epitope E f) NERK motif and g) any combination of (a) through (f) above, wherein the norovirus epitope and/or motif is from a norovirus strain that is different from the norovirus VP1 major capsid protein backbone.
