RECEPTEURS D'ANTIGENES CHIMERIQUES (CAR) SPECIFIQUES ANTI-HSP70 POUR UNE IMMUNOTHERAPIE ANTICANCEREUSE

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专利权人:

RINAT NEUROSCIENCE CORPORATION;CELLECTIS

发明人:

SMITH, JULIANNE,VALTON, JULIEN,JUILLERAT, ALEXANDRE,DUCHATEAU, PHILIPPE,SASU, BARBRA JOHNSON,RAJPAL, ARVIND

申请号：

CA2973524

公开号：

CA2973524A1

申请日:

2016.01.25

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from an anti-HSP70 monoclonal antibody, conferring specific immunity against HSP70positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating in particular leukemia.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/