The utility model relates to a medicine box with waterproof effect, which comprises a box body, a cover body, a main partition board and a plurality of auxiliary partitions. Through the main partition board and the plurality of auxiliary partition boards, the box body is separated from a plurality of containing spaces for placing medicines, and after the cover body is covered with the box body, the gap between the cover body and the box body is filled through the rubber strip arranged at the bottom edge of the cover body, so as to achieve the goal of waterproof and dustproof .一種具防水效果之藥盒，其包括有一盒體、一蓋體、一主隔板以及複數副隔板，透過主隔板與複數副隔板將盒體分隔出複數個可置放藥品之容置空間，並在蓋體在覆蓋於盒體後，透過蓋體底部邊緣所環設之膠條，填滿蓋體與盒體間之空隙，使其達到防水與防塵之目的。
