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Heterocyclic Antiviral compounds
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
BRAMELD, KENNETH,CARTER, DAVID,CHIN, ELBERT,DE VICENTE FIDALGO, JAVIER,LI, JIM,SCHOENFELD, RYAN,SJOGREN, ERIC,TALAMAS, FRANCISCO
申请号:
ES09780611
公开号:
ES2383273T3
申请日:
2009.07.15
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of the formula I ** Formula ** in which: R1 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, halogen, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, cyano, NRaRb, carboxy, ( C1-3 alkoxy) carbonyl, carboxamido, C1-3 amino-alkyl, (C1-3 acylamino) -C1-3 alkyl, C1-6 hydroxyalkoxy; R2 is selected from the group consisting of: (a) - [C (R8 ) 2] p-Ar1, (b) - [C (R8) 2] p-OAr1, (c) - (CH2) mC (>; = O) X, (d) -NR7C (>; = O) Ar4, ( e) -C 1-6 alkyl, (f) -C 1-6 alkyl alkyl, (g) C 1-6 alkoxy, (h) C 1-6 haloalkoxy, (i) C 1-6 hydroxyalkyl, (j) hydroxy, (k) halogen , (l) hydrogen, (m) phenoxysulfonyl, (n) -O (CH2) mAr1, (o) - [C (R8) 2] p-NReRf, (p) (E) - or (Z) -R10C>; = CR10Ar1, (q) -C≡CAr1 in which R8 regardless of its occurrence is hydrogen, carboxyl, (C1-3 alkoxy) carbonyl, carboxamido, hydroxy C1-3 alkyl, C1-3 alkyl, - (CH2) rNRgRh or cyano , R10 regardless of its occurrence is hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, cyano, (C1-3 alkoxy) carbonyl, carboxamido or (C1-3 alkoxy) -C1-6 alkyl, p is a number of c Eroa four and r is a number from 1 to 3; Ar1 is phenyl, naphthyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinolinyl, optionally substituted with independence one to three times by substituents chosen from the group consisting of (a) hydroxy, (b ) C1-6 alkoxy, (c) C1-6 alkyl, (d) C1-10 hydroxyalkyl of which one or two carbon atoms may have been optionally replaced by oxygen, provided that the replacement atoms do not form an oxygen-oxygen bond, ( e) (C1-3 alkoxy) -C1-6 alkyl, (f) halogen, (g) cyano, (h) (C1-6 alkoxy) carbonyl, (i) C1-6 alkylsulfonyl, (j) X1 (CH2) 1-6CO2H, (k) (C1-3 acylamino) -C1-6 alkyl, (l) (CH2) nNRaRb, (m) (CH2) nCONRaRb, (n) -O (CH2) nCONRaRb, (o) X2 ( CH2) 2-6NRgRh (p) X120-C1-6 hydroxyalkyl, (q) C1-6 haloalkyl or (r) carboxyl; Ra and Rb are (i) irrespective of their occurrence (a) hydrogen, (b) C1 alkyl -6, (c) C1-3 haloalkyl, (d) C1-6 acyl, (e) C1-6 alkylsulfonyl, (f) C1-6 haloalkylsulfonyl, (g) cycloalkyl C3-7 ulfonyl, (h) (C3-7 cycloalk
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