A method is disclosed for automatically determining a contrast agent injection protocol for a patient to be examined. An embodiment of the method includes provisioning a plurality of patient reference parameters, a plurality of contrast agent injection protocol parameters and a plurality of assignments of at least one given patient reference parameter with at least one given contrast agent injection protocol parameter; comparing of at least one patient parameter with the plurality of patient reference parameters, the patient parameter being based on patient information; selecting at least one patient reference parameter from the plurality of patient reference parameters based on the comparing; and determining at least one contrast agent injection protocol parameter from the plurality of contrast agent injection protocol parameters.