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Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
专利权人:
Kondareddiar Ramalingam
发明人:
Kondareddiar Ramalingam,Rolf E. Swenson
申请号:
US12553421
公开号:
US08105567B2
申请日:
2009.09.03
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compounds of the formula:Wherein R is selected from the group consisting of H, NH2, and NHBoc and R′ is selected from the group consisting of H, CH2Ph and tBu, optionally de-protected. Such compounds may be conjugated with a suitable molecule able to interact with physiological systems and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203Pb, 67Ga, 68Ga, 72As, 111In, 113In, 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi, 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, 51Cr, 167Tm, 141Ce, 168Yb, 88Y, 165Dy, 166Dy, 97Ru, 103Ru, 186Re, 188Re, 99mTc, 211Bi, 212Bi, 213Bi, 214Bi, 105Rh, 109Pd, 117mSn, 177Sn and 199Au, as well as the salts thereof with physiologically compatible bases or acids.
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