New pyrrolotriazine derivatives having the chemical structure of formula (I) are discl osed as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).本發明公開了具有化學式(I)的化學結構的新式吡咯並三嗪衍生物;以及其製備方法、包含其之醫藥組合物與其在治療上作為磷脂肌醇3-激酶(PI3Ks)抑制劑的用途。