磷脂醯肌醇-3-激酶(PI3K)抑制劑及MTOR抑制劑之組合农业专利-农业学术服务平台

发明人:: FRITSCH, CHRISTINE,弗里奇　克丽丝汀,弗里奇　克麗絲汀,GARCIA-ECHEVERRIA, CARLOS,嘉西亚　艾契佛利亚　卡洛斯,嘉西亞　艾契佛利亞　卡洛斯,HUANG, XIZHONG,黄锡忠,黃錫忠,MAIRA, SAUVEUR-MICHEL,麦拉　索弗尔　米歇尔,麥拉　索弗爾　米歇爾,弗里奇克丽丝汀,弗里奇克麗絲汀,嘉西亚艾契佛利亚卡洛斯,嘉西亞艾契佛利亞卡洛斯,麦拉索弗尔米歇尔,麥拉索弗爾米歇爾

摘要：: The present invention relates to a pharmaceutical combination comprising a phosphatidylinositol- 3-kinase (PI3K) inhibitor compound which is a 2-carboxamide cycloamino urea derivative or a pharmaceutically acceptable salt thereof and at least one mammalian target of rapamycin (mTOR) inhibitor or a pharmaceutically acceptable salt thereof； a pharmaceutical composition comprising such a combination； and the uses of such a combination in the treatment proliferative diseases, more specifically of mammalian target of rapamycin (mTOR) kinase dependent diseases.本發明係關於一種醫藥組合，包括磷脂醯肌醇-3-激酶(PI3K)抑制劑化合物，其為2-甲醯胺環胺基脲衍生物或其醫藥上可接受的鹽，及至少一種哺乳動物雷帕黴素(rapa-mycin)靶(mTOR)抑制劑或其醫藥上可接受的鹽；一種包括該組合之醫藥組合物；及該組合於治療增生性疾病(更特定為哺乳動物雷帕黴素靶(mTOR)激酶依賴性疾病)之用途。