Renata Chagas Bastos;Che-Hung Robert Lee;Ellen Jessouroun;Ivna Alana Freitas Brasileiro Da Silveira;Carl E. Frasch
发明人:
Ellen Jessouroun,Ivna Alana Freitas Brasileiro Da Silveira,Renata Chagas Bastos,Carl E. Frasch,Che-Hung Robert Lee
申请号：
US10566898
公开号：
US09173931B2
申请日:
2004.08.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
