SPLICE SWITCHING OLIGOMERS FOR TNF SUPERFAMILY RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE

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专利权人:

Ercole Biotech, Inc.;Santaris Pharma A/S; Inc.;Ercole Biotech

发明人:

Ørum, Henrik,Sazani, Peter L.

申请号：

AU2016203220

公开号：

AU2016203220A1

申请日:

2016.05.17

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016203220A120160609.pdf#####ABSTRACT The present invention relates to splice switching oligonucleotides or splice switching oligomers (SSOs). The preferred SSOs according to the invention target exon 7 of TNFR1 (TNFRSF1A) or TNFR2 (TNFRSF1A) pre-mRNA, typically resulting in the production of TNFR variants which comprise a deletion in part or the entire exon 7 respectfully. SSOs targeting exon 7 are found to result in a soluble form of the TNFR, which has therapeutic benefit for treatment of inflammatory diseases. The SSO's are characterized in that they are substantially incapable or incapable of recruiting RNaseH.

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中国工程科技知识中心

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http://www.ckcest.cn/home/