595386 Disclosed are peptide derived from antibodies with reactivity against a GPI linkage epitope, wherein the peptide consists of the amino acid sequence: [LKE]-[RG]-[GML-[LTY]-[LTG]-[PGN]-[DY]-[YAF] Also disclosed are methods of expressing said peptide, vaccine compositions comprising said peptide, and the use of said peptide in the production of a medicament for treating diseases such as autoimmune diseases, cardiovascular diseases, glucose intolerance, etc.