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Optimized Antibody Synthesis for the Treatment of Eye Diseases
专利权人:
INC.;GENENTECH
发明人:
申请号:
ARP180100673
公开号:
AR111249A1
申请日:
2018.03.22
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Claim 1: A group of antibodies consisting of (1) antibodies and (2) hyaluronic acid polymers covalently bind to the antibody.1. Polymer dispersion index (PDI) of A is 1.1 or less. Claim 19: The total number of antibodies in any claim 1-18,A. The antibody binds to a specific biological molecule, which is composed of vascular endocrine growth factor (VEGF).1. IL-1B;I-6;IL-6R;I-13;- 13R;PDGF;Angiography;2. AngiopoyetinaParagraph 2Page: 1AVB3 protoplastAVB5 and A5B1;Betacelulina;1. Appeal/People's Court;Erythromycin;Cofactor D;TNFA;Htra1;A vegetarianST-2 receptors and proteins genetically associated with AMD risk. Claim 22: Consolidated antibodies in claim 19,There, the antibody specifically binds to Vegf. Claim 23: Consolidated antibodies in claim 22,The antibody consists of the following six variable regions: (a) an HVR-H1, including the Dywih amino acid sequence (SEQ ID No.1);(b) HVR-H2, including GX1-TPXGX3 X8308; X8309; (YX8310 DSVX8311; X-831222 (SEQ ID No.2);If you have registered, please login first.X2 is ALA or ARG.X3 is Tyr or LysX83088 is THR or GLU.X830909 is ARG.Thailand...GLN or GLU,X8310 is a wing or GLU.X degree 8311 is Lys or GLU.X831222 is GLY or GLU;(c) HVR-H3, including Fvfflpyamdy amino acid sequence (SEQ ID No.3);(d) HVR-L1, including the amino acid sequence of Rasqx1 vstava (SEQ ID No.4),X1 is the place of ASP or ARG;(e) HVR-L2, including X1 ASFrys amino acid sequence (SEQ ID No.5),Anyone can view this photo.(f) HVR-L3, including the amino acid sequence of X1 QGYXPFT (SEQ ID No.6);In X1, it's GLN.ASN or THR,This is Ala.ASN,GLN or ARG. Claim 123: The pharmaceutical ingredients used in any 106-121 claim for the production of medicines for the treatment of eye diseases in patients.Reivindicación 1: Un conjugado de anticuerpo que comprende (i) un anticuerpo y (ii) un polímero de ácido hialurónico (HA) unido de forma covalente al anticuerpo, en donde el polímero de HA tiene un índice de polidispersión (PDI) de 1,1 o menos. Reivindicación 19: El conjuga
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