PROBLEM TO BE SOLVED: To provide a method capable of simply producing a stable and high-quality liposome preparation in which lipolysis is suppressed, capable of remarkably shortening production time on a middle or large scale and attaining remarkable cost reduction and capable of attaining uniform medicine-introducing amount.SOLUTION: The method for producing the liposome preparation comprises a medicine-introducing step for heating a mixed liquid of previously prepared liposome suspension with a medicine to a temperature not lower than film phase transition point of liposome or &le80°C by a rapidly heating means, in the method for producing the liposome preparation by using a remote loading method.COPYRIGHT: (C)2008,JPO&INPIT【課題】中・大規模での製造時間を大幅に短縮し大幅なコスト削減を達成することができ、かつ均一な薬物導入量を達成でき、脂質分解の抑制された安定で高品質のリポソーム製剤を簡便に製造しうる方法の提供。【解決手段】予め調製されたリポソームの懸濁液と、薬物との混合液を急速加熱手段により、該リポソームの膜相転移点以上の温度ないし80℃以下の温度に加熱してリポソーム内に薬物を導入する薬物導入工程を含む、リモートローディング法を用いるリポソーム製剤の製造方法。【選択図】なし
