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AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
专利权人:
Merck Sharp & Dohme Corp.
发明人:
Junying Zheng,Walter Won,Michael Berlin,Pauline Ting,Guoqing Li,Dong Xiao,Hongwu Wang,Robert Aslanian
申请号:
US15815212
公开号:
US20180193314A1
申请日:
2016.06.06
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof, wherein: “Z”, R1 and R2 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
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