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Aminopyrazine compounds with A2A antagonist properties
专利权人:
Merck Sharp &; Dohme Corp.
发明人:
Rongze Kuang,Pauline Ting,Amjad Ali,Heping Wu,Michael Berlin,Andrew Stamford,Hongwu Wang,Gang Zhou,David Kim,Qiaolin Deng,Yeon-Hee Lim,Younong Yu
申请号:
US15525788
公开号:
US10472347B2
申请日:
2015.11.13
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R1”, “RA-1”, “R2”, “R3”, and “Het” are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
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