BIN SHAO,CHIYOU NI,JIANG CHAO,JIANMING YU,LAYKEA TAFESSE,XIAOMING ZHOU
申请号：
BR112013006272
公开号：
BR112013006272A2
申请日:
2011.09.16
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The invention relates to substituted pyridine compounds of Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein R<；sup>；1a<；/sup>；, A<；sup>；1<；/sup>；, A<；sup>；2<；/sup>；, E, Z<；sup>；1<；/sup>；, and Z<；sup>；2<；/sup>；are defined as set forth in the specification. G is G-4.The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
