PURPOSE: An antimicrobial peptide derived from Thunnus albacares is provided to show effective antimicrobial activity against fish pathogenic microorganisms without harming the fish and the human body because the peptide does not have a hemolytic activity to erythrocytes of human and fish. CONSTITUTION: A peptide with an amino acid sequence of sequence number 1 or a variant thereof has an antimicrobial activity. The peptide or the derivative is derived from Thunnus albacares. The peptide or the derivative has an antimicrobial activity against gram positive bacteria and gram negative bacteria. The peptide or the variant does not damage erythrocytes of human or fish. A gene encodes the peptide or the variant. Antibiotics contain the peptide as an active ingredient.본 발명은 항미생물성 펩타이드에 관한 것으로서, 어류 병원성 미생물에 대하여 효율적인 항미생물 활성을 나타낼 뿐만 아니라, 인간 및 어류의 적혈구에 대한 용혈활성은 거의 없기 때문에, 양식어류에 대한 사료첨가제로 사용되거나, 항생제 대체제로 사용되더라도 어류 및 인체의 건강에 대한 위협요소를 제공하지 않는다.
